Spravato (Esketamine) in Tustin, California
Clinics
2 clinics shown
Enhance Health Group- Mental Health Treatment
Enhance Health Group operates a mental health and addiction treatment center in Tustin, located on Newport Avenue near the Orange County border. The practice provides outpatient services for adults addressing substance use disorders, including alcohol and drug dependencies, alongside general mental health conditions. Drug testing services are available on-site as part of treatment monitoring protocols. Specific modalities such as TMS, ketamine, or esketamine are not detailed in available listings; prospective patients should inquire directly about procedural treatment options.
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About Spravato (Esketamine)
Spravato is the brand name for esketamine, an FDA-approved nasal spray for treatment-resistant depression and major depressive disorder with suicidal ideation. It's derived from ketamine and works on the brain's glutamate system — a different mechanism than traditional antidepressants like SSRIs.
Treatment is administered only at REMS-certified clinics under direct medical supervision. Patients self-administer the spray under a clinician's guidance, then remain at the clinic for at least two hours of monitoring after each dose. The induction phase typically involves twice-weekly sessions for four weeks, followed by weekly or biweekly maintenance dosing depending on response.
Many patients report meaningful symptom improvement within the first one to two weeks — substantially faster than the 4 to 8 weeks typical of oral antidepressants. Spravato is taken alongside an oral antidepressant, not as a replacement.
The most common side effects are dissociation, dizziness, sedation, and elevated blood pressure during and shortly after dosing. These typically resolve within the two-hour monitoring window. Patients cannot drive on the day of treatment.
Most commercial insurance and Medicare cover Spravato for treatment-resistant depression with prior authorization. Clinics offering Spravato in our directory hold active REMS certification and are staffed to provide the required in-clinic monitoring period.