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Spravato (Esketamine) in San Francisco, California

Compare 11 Spravato (Esketamine) clinics in San Francisco, California that offer care for treatment-resistant depression and major depressive disorder. Review services, ratings, and contact details to find the right provider near you.
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Clinics

11 clinics shown

  • Cara Hoepner

    Cara Hoepner operates a mental health practice on Gough Street in San Francisco's Hayes Valley neighborhood. The clinic provides general mental health services for adults, though specific treatment modalities such as TMS, ketamine, or esketamine are not detailed in available information. Patients seeking specialized interventions for treatment-resistant conditions should contact the practice directly to confirm which therapeutic approaches are offered.

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  • Mindful Health Solutions - San Francisco

    Ketamine infusion therapy is administered at this Castro Street location for adults with treatment-resistant depression and other mood disorders. The clinic operates as part of Mindful Health Solutions' network of psychiatric treatment centers. Sessions are conducted under medical supervision, with patients monitored throughout the infusion process. The practice also provides psychiatric evaluations to determine treatment candidacy.

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  • Mindful Health Solutions - San Francisco (Post Street)

    TMS therapy and Spravato (esketamine) are administered at this downtown San Francisco clinic on Post Street, near Union Square. Mindful Health Solutions treats adults with treatment-resistant depression who have not responded adequately to prior antidepressant trials. The practice also provides psychiatric evaluations and medication management as part of comprehensive mental health care. Treatment protocols follow FDA-approved guidelines, with sessions conducted under medical supervision.

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  • Mindful.

    Mindful operates a mental health practice on South Park Street in San Francisco's SoMa district, providing psychiatric services for adults. The clinic's specific treatment modalities—including whether TMS, esketamine, or ketamine therapy are offered—are not detailed in available directory information. Patients seeking procedural treatments for treatment-resistant depression should contact the practice directly to confirm available services and insurance participation.

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  • Mindpath Health Psychiatrists & Therapists - San Francisco

    Mindpath Health operates a psychiatry and psychotherapy practice in San Francisco's Financial District on Montgomery Street. The clinic provides outpatient mental health services for adults, including psychiatric evaluations, medication management, and individual therapy. Specific procedural treatments such as TMS or ketamine are not detailed in available listings; patients seeking those modalities should confirm availability directly with the practice. Mindpath accepts most major insurance plans and offers both in-person and telehealth appointments.

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  • Numa Psychiatry & Psychedelic Medicine

    Numa Psychiatry & Psychedelic Medicine operates a psychiatry practice in San Francisco's Lower Pacific Heights neighborhood on Bush Street. The clinic provides psychiatric evaluations and medication management, with a stated focus on psychedelic-assisted therapies based on its name, though specific treatment protocols such as ketamine or esketamine are not detailed in available listing data. Patients seeking information about psychedelic medicine offerings should contact the practice directly to confirm which treatments are currently administered and under what clinical frameworks.

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  • Quantum Integral Healing Arts

    Quantum Integral Healing Arts operates a mental health clinic on 24th Street in San Francisco's Noe Valley neighborhood, combining psychiatric services with complementary modalities including acupuncture, Chinese medicine, and massage therapy. The practice treats adults through an integrative approach that addresses both conventional psychiatric care and alternative wellness methods. Specific psychiatric treatment offerings such as TMS, ketamine, or esketamine are not detailed in available listings.

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  • Sunset Mental Health Services

    Sunset Mental Health Services operates as a public mental health facility in San Francisco's Outer Sunset neighborhood on 41st Avenue. The clinic provides psychiatric evaluations and outpatient mental health services through the city's public health department. Specific treatment modalities such as TMS, esketamine, or ketamine therapy are not detailed in available information; prospective patients should inquire directly about specialized depression treatments and current service offerings.

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  • UCSF Department of Psychiatry

    The UCSF Department of Psychiatry operates a psychiatric hospital and outpatient services at 675 18th Street in San Francisco's Potrero Hill neighborhood. As part of the University of California San Francisco medical system, the department provides psychiatric evaluations, medication management, and inpatient care for adults with serious mental illness. Specific outpatient treatment modalities such as TMS, esketamine, or ketamine therapy are not detailed in available listings. The facility serves as both a clinical care site and an academic training center for psychiatric residents and fellows.

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  • UCSF Langley Porter Psychiatric Hospital and Clinics

    UCSF's Langley Porter Psychiatric Hospital and Clinics operates a university-affiliated psychiatric facility on Divisadero Street in San Francisco, providing inpatient and outpatient mental health services. The hospital is part of the UCSF Department of Psychiatry and Behavioral Sciences, serving adults and adolescents with acute psychiatric conditions requiring hospitalization or intensive outpatient care. Specific treatment modalities such as TMS, esketamine, or ketamine are not detailed in available listings; patients should contact the facility directly to confirm availability of procedural interventions beyond standard psychiatric hospitalization and medication management.

  • UCSF Psychiatry Clinic

    The UCSF Psychiatry Clinic operates on the fourth floor of 675 18th Street in San Francisco's Mission Bay neighborhood, providing psychiatric evaluations and medication management for adults. As part of the university medical system, the practice focuses on general outpatient psychiatry rather than specialized procedural treatments. Patients seeking TMS, esketamine, or ketamine therapy should confirm availability directly, as these services are not specified in the clinic's standard offerings.

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About Spravato (Esketamine)

Spravato is the brand name for esketamine, an FDA-approved nasal spray for treatment-resistant depression and major depressive disorder with suicidal ideation. It's derived from ketamine and works on the brain's glutamate system — a different mechanism than traditional antidepressants like SSRIs.

Treatment is administered only at REMS-certified clinics under direct medical supervision. Patients self-administer the spray under a clinician's guidance, then remain at the clinic for at least two hours of monitoring after each dose. The induction phase typically involves twice-weekly sessions for four weeks, followed by weekly or biweekly maintenance dosing depending on response.

Many patients report meaningful symptom improvement within the first one to two weeks — substantially faster than the 4 to 8 weeks typical of oral antidepressants. Spravato is taken alongside an oral antidepressant, not as a replacement.

The most common side effects are dissociation, dizziness, sedation, and elevated blood pressure during and shortly after dosing. These typically resolve within the two-hour monitoring window. Patients cannot drive on the day of treatment.

Most commercial insurance and Medicare cover Spravato for treatment-resistant depression with prior authorization. Clinics offering Spravato in our directory hold active REMS certification and are staffed to provide the required in-clinic monitoring period.